| Class I Subclinical Neuropathy* |
Abnormal electrodiagnostic tests (EDX) |
| Decreased nerve conduction velocity |
| Decreased amplitude of evoked muscle or nerve action potential |
Abnormal quantitative sensory testing (QST) |
| Vibratory/tactile |
| Thermal warming/cooling |
| Other |
Abnormal autonomic function tests (AFT) |
| Diminished sinus arrhythmia (beat-to-beat heart rate variation) |
| Diminished sudomotor function |
| Increased pupillary latency |
Class II Clinical Neuropathy |
| Diffuse neuropathy |
| Distal symmetric sensorimotor polyneuropathy |
| Primarily small fiber neuropathy |
| Primarily large fiber neuropathy |
Mixed |
| Autonomic neuropathy |
| Abnormal pupillary function |
| Sudomotor dysfunction |
| Genitourinary autonomic neuropathy |
| Bladder dysfunction |
| Sexual dysfunction |
| Gastrointestinal autonomic neuropathy |
| Gastric atony |
| Gall bladder atony |
| Diabetic diarrhea |
| Hypoglycemic unawareness (adrenal medullary neuropathy) |
| Cardiovascular autonomic neuropathy |
| Hypoglycemic unawareness |
Focal neuropathy |
| Mononeuropathy (upper or lower extremity) |
| Mononeuropathy multiplex |
| Plexopathy |
| Polyradiculopathy (can occur with diffuse neuropathy) |
| Cranial mononeuropathy |
* Neurological function tests are abnormal, but no neurological symptoms or clinically detectable neurological deficits indicative of a diffuse or focal neuropathy are present. Class I "Subclinical neuropathy" is further subdivided into Class Ia if an AFT or QST abnormality is present, Class Ib if EDX or AFT and QST abnormalities are present, and Class Ic if an EDX and either AFT or QST abnormalities or both are present.
Adapted from Consensus Panel: Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy. Diabetes 1988; 37:1000.
